As cliched as it sounds, if you have an original voice and an original idea, then no matter what anybody says, you have to find a way to tell that story.
Essentially, there's no scientific evidence whatsoever that could ever be presented to me that would wipe out my fundamental spiritual beliefs.
The interpretive element of 'Lost' - the fact that you immediately need, as soon as the episode is over, to seek out a community of people to express your own thoughts about it, understand what they thought about it and form an opinion - that's the bread and butter of the show.
A lot of writers whom I love, admire and call friends share this feeling, which is this fundamental idea that we're frauds. That we will be pushed out on to the stage, and it will be revealed that the emperor has no clothes.
I think that 'The Shield' was a phenomenal series finale.