Huge open source organizations like Red Hat and Mozilla manage the collaboration of hundreds of people who don't know one another and have spent no time hanging around the water cooler.
Very few entrepreneurs start their business on the back of market research. Instead, they have tremendous zeitgeist, honed by paying attention to where they are.
All businesses and jobs depend on a vast number of people, often unnoticed and unthanked, without which nothing really gets done. They are all human and deserve respect and gratitude.
The cell phone has become the adult's transitional object, replacing the toddler's teddy bear for comfort and a sense of belonging.
I don't think a true company - one that builds sustainable value - can ever only exist online or remotely.
The best remote companies I've seen do almost everything online, via email and telephone. But they also get together face to face on a regular basis.