Know what you're trying to do before you do it. Turning knobs at random isn't enlightening any more than throwing paint at a wall blindfolded will let you paint a nice picture.
Harmonics are vibrations a fraction of the length of the vibrating string, which add higher-pitched and more complex content to the notes. With a dull instrument, the harmonics die out, but with a sustaining instrument, the harmonics continue to sound along with the fundamental note.
Doubt the conventional wisdom unless you can verify it with reason and experiment.
If I'm working as an engineer for another band, the responsibility for brilliance pretty much rests on their shoulders. I think I'm pretty good, but I'm not good enough to turn a trout into a sausage, or the other way around.
In the late '80s and early '90s, there was a slightly retro drum sound that was popular in hip-hop music called the 808 bass drum sound. It was the bass drum sound on the 808 drum machine, and it's very deep and very resonant, and was used as the backbone as a lot of classic hip-hop tracks.
You see something happen to a population whereby everyone adopts something that's just preposterous in a way that makes it normal instantly. If any one person prior to the rash of puka shells, for example, was seen wearing puka shells, he would look like an idiot. But when everyone is wearing them, it instantly makes them normal.