I would cling to unhappiness because it was a known, familiar state. When I was happier, it was because I knew I was on my way back to misery. I've never been convinced that happiness is the object of the game. I'm wary of happiness.
I think of House as a deeply moral character, though some would no doubt argue with me. He does not judge. Beyond his normal tetchiness, there were no more than a half-dozen moments of actual condemnation from him. He understood lies and also why you lied, and there was an absolution there that is very, very appealing.
I run six-to-eight miles a day, plus weights and aerobics in the lunch hour. I also lie a lot, which keeps me thin.
I wouldn't be able to act like Al Pacino or play the piano like Dr. John, But I could probably act better than Dr. John and play the piano better than Al Pacino.
I think good-looking people seldom make good television. And American television studios almost concede before they start: 'Well, it won't be good, but at least it'll be good-looking. We'll have nice-looking girls in tight shirts with F.B.I. badges and fit-looking guys with lots of hair gel vaulting over things.'
The glory of American television is Dennis Franz.
I have always stuck up for Western medicine. You can chew all the celery you want, but without antibiotics, three quarters of us would not be here.
I never went to drama school, I don't have any certificates saying: 'He's a qualified actor.' But I did think that 'House' was something I didn't have to apologise for. It was something I was really proud of and it was sort of... whether you liked it or not, it was undeniable.
I have been instrumental in banning bottled water on the set. It hasn't gone that well with the crew... so I replaced it with tequila.
It's easier for a camel to pass through the eye of a needle than for a rich man to make a blues record.
I grew up with an impatience with the anti-scientific. So I'm a bit miffed with our current love affair with all things Eastern. If I sneeze on the set, 40 people hand me echinacea. But I'd no sooner take that than eat a pencil. Maybe that's why I took up boxing. It's my response to men in white pajamas feeling each other's chi.
I think pain is a very - it's an extremely hard thing to empathize moment to moment. And you often don't remember your own pain, you know, that moment that you broke a limb or you burned yourself or, I think, this is a common thing that women talk about with childbirth, that the memory of the pain is hard to summon up and relive, thankfully.
I think there is a basic comfort in clever people who know things.
I didn't realize House would be the central character, more the bitter comic relief appearing occasionally. I relish his wounded nature - the lameness, the scarred Byronic hero.
I think actors are attracted to the idea of other identities and concealing themselves behind some other identity.
I couldn't imagine what Fox thought they were doing, contemplating such a jagged protagonist for a prime-time drama. I only knew that I wanted the role very much.
I personally believe that the iPod is a frankly corrosive device because it encourages you to surround yourself with your favorites. The whole idea of a playlist is to surround yourself with your favorite things, and the interesting thing is that when you do that, they cease to be your favorites.
I'm finding it increasingly difficult to simply walk down the street. In New York, I dashed in to buy a big pair of sunglasses to conceal myself, but the guy behind the counter shouted 'Hey! It's Dr. House.'
I don't have a single complete show or movie or anything else that I could look at and say, 'Nailed that one.' But endless dissatisfaction is, I suppose, what gets us out of bed in the morning.
Driving a motorcycle is like flying. All your senses are alive. When I ride through Beverly Hills in the early morning, and all the sprinklers have turned off, the scents that wash over me are just heavenly. Being House is like flying, too. You're free of the gravity of what people think.