One of the most intriguing problems is to understand the precise nature of time, especially with regard to the big bang, the big crunch and the long-term future of an open universe.
Indeed, it is not clear whether it is meaningful to talk about 'after' the big crunch, just as it is not clear whether it is meaningful to talk about what happened 'before' the big bang. These questions are not necessarily meaningless, but the fact is we simply do not know.